Sentence examples for multiple receptor pathways from inspiring English sources

Thus, FGF19 acts through multiple receptor pathways to elicit pleiotropic effects in regulating nutrient metabolism and cell proliferation.

This results in the activation of multiple receptor pathways, including HER2-related receptors and non-HER receptors such as the IGF-IR, which appear to be involved in a cross talk with HER2 in resistant cells (Berns et al, 2007).

None of the published models have included multiple receptor pathways for the WUS-repressing signal, and in this paper we use computational modeling to investigate details of receptor and ligand turnover, interactions, and signaling.

Increased signalling through the PI3-K/Akt pathway could induce the activation of multiple receptor pathways that include ErbB-related receptors or non-ErbB receptors such as IGF1-R, which seems to be involved in a cross-talk with ErbB2 in resistant cells (Lu et al, 2001).

It is tempting to speculate that this expression signature indicates a state of a parallel, synergistic activation of multiple receptor pathways (receptor tyrosine kinases, G-protein-coupled receptors and nuclear transcription factors), which vastly promote tumour cell proliferation and angiogenesis in the tumour stroma.

Our work demonstrates that adenosine, as well as ATP or ADP, participates in inflammasome activation via multiple receptor signalling pathways.

An initial event of inflammation in ischemic stroke is the activation of microglia, leading to production of both pro- and anti-inflammatory mediators acting through multiple receptor signaling pathways.

These include disruptions of KIDINS220, a functional mediator of multiple receptor signalling pathways and essential for cortical development [ 25, 26]; CHIC2, frequently deleted/rearranged in myeloid malignancies [ 27]; and KCND2, encoding a potassium voltage-gated channel, which is expressed in both neuronal and glial cells and has been shown to regulate ERK signalling in ganglioglioma [ 28].

Additionally, like norepinephrine, octopamine acts through multiple receptor-signaling pathways having wide-ranging influences over cellular physiology.

There is growing appreciation that HSC express multiple receptors and pathways that are typically considered to be part of innate immune responses, including expression of TLRs and inflammasome components [ 7, 8].

Pathways identified as important in hepatocarcinogenesis include the Wnt/β-catenin signaling pathway, insulin/insulin-like growth factor pathway, multiple receptor tyrosine kinases activating downstream of PI3K/Akt and MEK/ERK signaling, and the TGF-β, interferon-inducible, mTOR and hedgehog signaling pathways [ 10- 13].