Sentence examples for multiple receptor conformers from inspiring English sources

Herein we report multiple receptor conformers based molecular docking as a practical alternative to account for the receptor flexibility.

Our study concludes that multiple receptor conformers based molecular docking can be an alternative to study the effect of receptor flexibility in ligand binding and fluorine directed modifications can improve drug efficacy.

The second type is referred to docking with multiple receptor structures, using pre-generated receptor conformers (Knegtel et al. 1997).

Selective inhibition of integrin function by antibodies specific for ligand-occupied receptor conformers.

Next, a flexible-ligand static-receptor small-scale virtual screening was performed on each of the receptor conformers, from which several pockets were selected for the following generation.

There was no evidence for expression of multiple receptor subtypes.

In particular, for several receptor conformers, decoys systematically outranked true binders and were assigned very high scores which, in turn, inflated their final position in our MRC-VLS.

Some of the receptor conformers used here were actually extracted from co-crystals bound to known binders in the set (see also Table S3 in the Supporting Information).

An inverting mutation does not change significantly the p Ka values of the attractant and repellent receptor conformers; rather, the relative sizes of the conformer pools is increased 6−10-fold in favor of the repellent conformer with the outwardly connected Schiff base.

That is, the direction of the PSB deprotonation is governed by which of the two alternative conformers is present in the unphotolyzed state, namely, the attractant or the repellent signaling receptor conformers, which show CP- or EC-directed PSB deprotonations, respectively.

Immune sensing of a microbe occurs via multiple receptors.