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It is known that the CCL-induced inflammatory response cascade is biologically redundant, i.e. the CCLs have multiple receptor specificities.
Multiple receptor specificities of chemokines point to the need of approaches targeting the chemokine ligands rather than a single chemokine receptor.
Similar(58)
The second type is referred to docking with multiple receptor structures, using pre-generated receptor conformers (Knegtel et al. 1997).
Studies in influenza receptor specificity have shown that specific amino acid substitutions can alter receptor binding site and binding specificity, which in turn, alters receptor preference [ 11- 13].
Despite this, the search for novel TLR signalling components has continued [2] motivated in part by the fact that the above mentioned signalling components are common to multiple TLRs and so only partially explain the receptor specificity apparent in TLR responses [3].
Receptor specificity was assessed with unlabeled exendin-3.
And single amino acid changes can change receptor specificity.
Structure-guided optimization of the crebanine scaffold is likely to further increase the receptor specificity.
This implies that minor topological changes can significantly alter the receptor specificity.
Each receptor can bind multiple chemokines within its class and each chemokine can bind multiple receptors.
The DA 2 receptor specificity is proven by the reduction of the inhibitory effects of both, DA and VAC BNO 1095 by haloperidol, a DA 2 receptor blocker 3.
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