Sentence examples for multiple receptor epitopes from inspiring English sources

Recent work demonstrating antibody cocktail-induced synergistic downregulation of EGFR motivated our design of cetuximab-based antibody fibronectin domain fusion proteins that exploit downregulation-based EGFR inhibition by simultaneously targeting multiple receptor epitopes.

Re-emerging of the respective receptor epitopes was measured by FACS analysis.

Designing strategies to target multiple receptors or, never explored, multiple epitopes on the same receptor may modulate the biodistribution properties of these nanomaterials.

Each receptor can bind multiple chemokines within its class and each chemokine can bind multiple receptors.

The viral fusion model, involving specific recognition events leading to unmasking of the co-receptor epitopes, is consistent with the triggered release of fusogenic conformations in other enveloped viruses and as such offers multiple opportunities for intervention.

Hence, targeting nanocarriers to multiple epitopes or receptors holds promise to control distribution of drug delivery nanomaterials in the body.

However, to avoid the difficult task of identifying a molecular architecture only present on oligomers, we have focused on a more general approach based on the hypothesis that all oligomers expose multiple identical epitopes and therefore would have an increased binding to a multivalent receptor.

This region possesses multiple linear epitopes between amino acids (aa) 384 410 that are important for antibody recognition and binding scavenger receptor class B type I (SR-BI), a lipoprotein receptor molecule essential for HCV entry (Bartosch et al., 2003c; Scarselli et al., 2002).

It has been shown that the host cell surface receptor-binding motif of the E protein maps to EDIII [ 34]; further serotype-specific multiple neutralizing epitopes have been localized to this domain [ 35- 37].

These responses were broadly directed against multiple Gag epitopes, both previously reported and some novel epitopes.

Influenza viruses possess multiple conserved epitopes which are used for designing universal vaccines.