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While multiple receptor clusters can form on individual myofibers, absence of an activity-independent pathway may preferentially integrate newly synthesized AChRs into existing endplates, lowering the incidence of multiple clusters relative to the γ/ε-fc mice.
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The ability of Mtb to engage multiple receptors (or receptor clusters) simultaneously might be an evolutionary advantage for its pathogenesis: in the absence of a single receptor, phagocyte infection by mycobacteria can be efficiently supported by alternative receptors.
Annotation of the clusters with human disease associations revealed that multiple disorders map to the network, with a significant correlation of schizophrenia within the glutamate receptor clusters.
The second type is referred to docking with multiple receptor structures, using pre-generated receptor conformers (Knegtel et al. 1997).
What is the significance of adaptor binding to receptor clusters?
The simultaneous binding of multiple ligands to multiple cellular receptors can lead to receptor clustering.
The IL-1R/TLR superfamily can be clustered into multiple receptors, which all play a crucial role in both innate and adaptive inflammatory systems [ 12].
Thus, our findings are consistent with the interpretation that the patient's MuSK mutants fail to activate a signaling cascade responsible for multiple aspects of synapse formation, including receptor clustering, postsynaptic membrane development and presynaptic differentiation.
Syntenin is a scaffolding-PDZ domain-containing protein involved in multiple biologic functions, including syndecan binding and recycling, receptor clustering, protein trafficking, signal transduction, and regulation of the transcription factor Sox4 proteasomal degradation [ 2- 7].
The major-cluster chemokines usually bind to multiple receptors and often do not correspond well between species.
The above findings suggest that Rho GTPases influence AChR aggregation in multiple ways, but little is known about how the receptor clustering process is affected by other proteins that also regulate actin polymerization.
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