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L.K. Dixon summarizes the multiple host pathways that are targeted at multiple levels by African swine fever virus.
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Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) is a multifunctional protein playing a crucial role in diverse steps of the viral replication cycle and perturbing multiple host cell pathways.
Targeting multiple host regulatory pathways through a single effector molecule would allow bacteria to more efficiently modulate complex host signaling networks and finely tune a specific environment for their lifestyle.
Nevertheless, incredibly versatile interaction of the bacterial protein with host molecules suggests that, upon delivery, CagA may act as a pathogenic scaffold/adaptor, which simultaneously perturbs multiple host signalling pathways and thereby promotes transformation.
CagA acts as an initiator that activates multiple host cell signaling pathways via direct or indirect impacts on vital signaling proteins, thereby leading to signaling pathway-dependent oncogene upregulation (Table 1).
Using gene-expression arrays we found that multiple host cell signal transduction pathways were activated by ATIII in HIV-1 infected cells but not in uninfected controls.
Two main genes by which the virus develops cancer are Tax and HBZ; playing an essential role in angiogenesis in regulating viral transcription and modulating multiple host factors as well as apoptosis pathways.
This study identified multiple host genes throughout the oxidative BER pathway that were required for efficient HIV infection.
Taken together, these findings suggest that host restriction of RNA virus replication in LD652 cells is mediated by multiple host factors including those involved in RNAi-, NF-κB, and Ub-related pathways.
Together, these findings revealed a strong mechanistic connection underlying simultaneous recognition of multiple host proteins by EspG, and suggested that the scaffolding properties of a bacterial effector protein may allow selective control over signaling pathways at the Golgi apparatus.
In contrast, only 3 clusters came from multiple host species.
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