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Multiple cellular proteins are covalently modified (e.g., phosphorylated/dephosphorylated) at several sites, which leads to diverse signaling activities.
As an example, we discuss the recent multi-scale analysis of Adenoviral protein E4-ORF3 that reveals a new type of multi-functional polymer that disrupts multiple cellular proteins.
Multiple cellular proteins including growth factors, hormones, metalloproteinases and cell receptors are synthesized as inactive precursors [13], [14].
These studies combine to indicate that multiple cellular proteins regulate AID, and several of these have yet to be identified.
The results from the protein microarray analysis indicated that phosphorylated Y992 (pY992) bound to multiple cellular proteins, serving as a multifunctional docking site of EGFR [38].
Mdm2 may impart some of its tumorigenic properties by increasing the degradation of multiple cellular proteins.
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Biological networks that are experimentally derived are given by a binary representation of validated interactions occurring on multiple cellular levels, e.g., between proteins, proteins and DNA, proteins and RNA, RNA and RNA.
Arabidopsis CPK1 was the first CPK to be characterized, and is known to be activated by phospholipids and 14-3-3 14-3-3 14-3-3ch are small, highly conserved eukaryotic proteins that regulate multiple cellular enzymes, including protein kinases [ 8].
Due to the presence of ATPase activity and involvement in multiple cellular processes these proteins have been categorized as AAA+ proteins (ATPases associated with multiple cellular processes).
Ad has a strictly regulated infection cycle where multiple viral and cellular proteins interact to complete the viral replication program to generate infectious virus particles.
More recent immuno-EM analyses revealed that the intranuclear crystals reacted with anti-hexon, anti-penton base and anti-fiber knob antibodies [43], as well as with protein kinase CK2 and dsRNA-activated protein kinase PKR antibodies, leading to the assumption that multiple viral and cellular proteins were components of the crystals [44].
Related(20)
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