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Also, the increase in AOPP may be due to the interaction of ROS with various cellular proteins (Meaney et al., 2008).
Oxidative stress resulting in excessive generation of ROS is a compelling initiator of DNA damage along with damage to various cellular proteins and other macromolecules.
To test this hypothesis, we first investigated the interaction between USP7 and the Herpes simplex virus type 1 (HSV1) regulatory protein ICP0 (also known as Vmw110), which is the first identified USP7-interacting protein and regulates the lytic and latent viral infection through inducing proteasomal degradation of various cellular proteins (Boutell and Everett, 2013).
Hsp90 is a molecular chaperone that drives folding and stabilization of various cellular proteins, including BRAF.
These proteins poly-ubiquitinate various cellular proteins, thereby targeting them for proteasomal degradation [ 81].
BCR-ABL is predominantly localized in the cytoplasm where it interacts with various cellular proteins.
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Moreover various cellular regulatory proteins, including the Rb tumor suppressor family members, bind Mcm2-7 and inhibit its activity.
This critical regulatory process is accomplished by activating the caspase cascade that results in the degradation of various important cellular proteins.
These PKLNKs in chimpanzee might be involved in various cellular processes through protein-protein interaction.
Ammonia is toxic to the cells leading to inhibition of various cellular activities like protein glycosylation, protein synthesis, cell viability, and so forth.
Membrane proteins play important roles in various cellular processes, and the protein-protein interactions involved in these processes may provide further information about molecular organization and cellular pathways.
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