As a molecular chaperone, HSp60 appears to have diverse effects on molecular surveillance functions in order to maintain the proper function and homeostasis of multiple cellular pathways under stress conditions.
The constitutive activation of NF-κB contributes to multiple cellular outcomes and pathophysiological conditions such as rheumatoid arthritis, asthma, inflammatory bowel disease [ 3], AIDS [ 4] and cancer [ 5].
The constitutive activation of NF-κB contributes to multiple cellular outcomes and pathophysiological conditions such as rheumatoid arthritis, asthma, inflammatory bowel disease, AIDS and cancer.
The primordial function of autophagy has long been recognised, but its significance in multiple cellular roles and various pathological conditions, including cancer, is only now being revealed (Gozuacik and Kimchi, 2007; Lerena et al, 2008; Mizushima et al, 2008).
Drugs with nitro groups generate free radicals under anaerobic growth conditions, and drugs with peroxide groups generate radicals under aerobic growth conditions, both affecting multiple cellular pathways.
Owing to its diverse functions, TrkB expression is regulated at multiple steps in response to various cellular conditions [22], [23], [24].
ER α ubiquitination can be mediated by multiple E3 ubiquitin ligases in response to changing cellular conditions.
Redox imbalance generates multiple cellular damages leading to oxidative stress-mediated pathological conditions such as neurodegenerative diseases and cancer progression.
Through this mechanism, several miRNA mRNA pairs have been described as critical in the regulation of multiple cellular processes, including early embryonic development and pathological conditions.
