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The observation that decellularized scaffolds still contain many cellular proteins, although at decreased abundance, indicates that elimination of DNA does not assure adequate removal of all cellular material.
Since rafts are believed to enrich viral proteins and deplete many cellular proteins they represent the first concentration step in the assembly of a virus particle that contains very little cellular proteins (Veit and Thaa, 2011).
Indeed, a large scale analysis indicates that many cellular proteins are at risk of undergoing this kind of deleterious transition; explaining how oxidative stress can impact cell proteostasis and subsequently lead to the onset of pathological states.
This protein is a ubiquitin-like protein which is conjugated to many cellular proteins [36].
PKCε also regulates many cellular proteins by phosphorylation, e.g., it phosphorylates cytoskeleton proteins [35].
Once activated Akt acts on many cellular proteins including mTOR, caspase 9, Bad, IKK, and GSK3β.
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CALM regulates many cellular protein kinases, phosphatases and transmembrane ion transporters, mainly in a calcium dependent manner.
clpXP encodes a proteolytic system involved in turnover of many key cellular proteins including many involved in DNA metabolism (Baker and Sauer, 2006), and is essential for the transition from growth to stationary phase.
Plasmalogens are enriched in lipid raft microdomains (LRM), cholesterol-rich regions of membranes where many cellular signaling proteins are concentrated (Pike et al., 2002; Rodemer et al., 2003).
Products of lipid peroxidation such as malondialdehyde, can inactivate many crucial cellular proteins [37].
Among many other cellular proteins, identification of these three host proteins has increased our understanding of how HIV would interact with its host proteins.
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many cellular activities
many cellular responses
many catabolic proteins
many nucleolar proteins
many cellular conditions
many other proteins
many different proteins
many cellular events
many cellular pathways
many cellular components
many oncogenic proteins
many cellular substrates
many cellular processes
many cellular factors
many cellular transformations
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