► A triple-input AND logic gated sensor using multiple cellular consortia.
Transient receptor potential (TRP) cation channels are unique cellular sensors that are involved in multiple cellular functions, ranging from transduction of sensory signals to the regulation of Ca2+ and Mg2+ homoeostasis.
Despite the advanced capabilities of the cellular sensors comprising only single cell type populations, systems containing multiple cell type populations might lead to more complex and high level functions through intercellular communication and cooperation (Brenner et al., 2007; Prindle et al., 2012; Weber et al., 2007).
The protein kinases AMPK and mTOR can function as sensors of metabolic impairment, whose activation by energy stress controls multiple cellular functions.
The sensor strategy is also applicable to in situ quantification of multiple cellular lipids or a single lipid in the opposing leaflets of cell membranes.
Allosteric but non-obligatory coupling of multiple stimuli to the opening of channel pore allows TRP channels to serve as polymodal cellular sensors.
Heme serves multiple cellular and systemic roles ranging from oxygen carrier in globins and electron transport in cytochromes to gas sensor in various proteins, i.e., Ec DOS, soluble guanylate cyclase, and CooA.
First, we identified significant global changes across multiple cellular pathways.
Similar to the simultaneous co-existence of multiple cellular networks in the same coverage area with distinct, at times overlapping clientage, it is expected that in near future multiple sensor networks with different sensing capabilities would co-exist in the same area.
Cancer cells exhibit deregulation in multiple cellular signaling pathways.
