Sentence examples for much lower affinity from inspiring English sources

TypeI binding sites show high affinity for PACAP38 and PACAP27 (Kd = approximately 0.5 nM) and much lower affinity for VIP (Kd > 500 nM) [5 8].

CBD has much lower affinity for CB1 or CB2 receptors, and acts as an antagonist of CB1 and CB2 agonists such as THC [276].

Hydrous Al oxides and clay minerals have a much lower affinity for adsorption of As III) than do amorphous and crystalline hydrous Fe oxides.

Pig NPY (pNPY) analogs containing the segment 19 23 from human PP (hPP) bound to the Y-receptors with much lower affinity than NPY itself.

However, pancreatic beta-cells also express the SERCA3 subtype (Varadi et al. 1996), which has a much lower affinity for Ca2+ (1100 nmol/L) than does SERCA2 (270 nmol/L) (Lytton et al. 1992).

In receptor binding assays, MJ15 displayed a high affinity for rat cannabinoid CB1 receptor (Ki = 27.2 pM, and IC50 = 118.9 pM), but a much lower affinity for rat cannabinoid CB2 receptor (only 46% inhibition at 10 μM).

It was hypothesized that even though gold-to-cobalt spillover occurred during reduction in Au Co/Al2O3, the great separation between the gold and cobalt crystallites, combined with gold's much lower affinity for hydrogen activation adversely affected the efficiency of the spillover process in the hybrid sample.

2-Amino-3-[3-hydroxy-5-(2-thiazolyl)-4-isoxazolyl]propionic 2-Amino-3-[3-hydroxy-5- 2-thiazolyl -4-isoxazolyl]propionicfinity for native kainic acid (KA) receptors, whereas (S)-E-4-(2-Amino-3-[3-hydroxy-5- 2-thiazolyl -4-isoxazolyl]propionicy 2-Amino-3-[3-hydroxy-5- 2-thiazolyl -4-isoxazolyl]propionicty 2-Amino-3-[3-hydroxy-5- 2-thiazolyl -4-isoxazolyl]propionic

The C2 domain of Protein-G from Streptococcus is a multi-specific protein domain; it possesses a high affinity (KD ~ 10 nM) for the Fc region of the IgG, but a much lower affinity (KD ~ low μM) for the constant domain of the antibody fragment (Fab), which limits some of its applications.

Thrombin is a serine protease with high affinity for PAR1 and much lower affinity for PAR4 receptors [12], [15].

This probably reflects a much lower affinity of these drugs for a yet unidentified target in Leishmania compared with their high affinity for HIV peptidase [33].