Sentence examples for significantly lower affinity from inspiring English sources

Protein ligand docking results indicated similar affinities for HSA of both the AETP moiety and a PEG fragment, and a significantly lower affinity for the RGD peptide.

In our competitive binding assay, unlike reported for other assays in the literature [18], a significantly lower affinity for natGa-10 (IC50 of 29.5 ± 6.6 nM) was determined compared to [natGa]HBED-CC-Ahx-KuE (IC50 = 6.1 ± 0.8 nM).

Interestingly, NOD2 displayed a significantly lower affinity for RIPK2 compared to NOD1.

In primigravidae, antibodies in HIV positive women also showed significantly lower affinity to VAR2CSA DBL5ε.

Such a lack of effect may reflect the significantly lower affinity of LCA for PXR, with significant effects only being observed at much higher agonist concentrations.

These data imply that in the absence of Hfq, binary complexes still form but relatively slowly in both cases and with significantly lower affinity.

Albeit all compounds show significantly lower affinities than rimonabant, this fact could be used to demonstrate that affinities and selectivity are influenced by the chemical structure and length of the spacer and might be helpful for designing bivalent probes for other GPCR receptors.

Jin et al. were also able to show that biotinylated exendin-4 derivatives showed no significantly lower affinities compared to unmodified exendin-4 when conjugated at the same positions [[17]].

When SPR analysis was performed in the direct format, in which PA was immobilized on the sensor chip, significantly lower affinities were obtained (Fig. 4; Table 2).

It should be noted that the affinity of the WT and the F14AW89A Evasin-1 proteins was measured on immobilized chemokine for a direct comparison, which consistently results in significantly lower affinities (results not shown).

These binding data suggest that ZFa ZF5, 6, and 7 have significantly lower affinities for dsRNA than ZFa ZF1, 2, or 3.