Sentence examples for much weaker affinity from inspiring English sources

We observed NMR spectra characteristic of tight binding at low micromolar concentrations (2 5 μM eIF4E) but much weaker affinity at more typical NMR concentrations (50 200 μM).

The purines, adenine and guanine, have a strong affinity for the Ni-IDA matrix, while the pyrimidines, cytosine and thymine, have a much weaker affinity [6].

The NH2-terminal domain of IN (IN1 55) and the central core domain of IN (IN51 212) showed much weaker affinity compared to the C-terminal domain (IN201 288).

In addition these antibodies displayed a much weaker affinity for EBNA-1 and dsDNA making them less desirable to use in our initial attempt to identify epitopes in EBNA-1 that play a role in cross-reactivity to dsDNA.

Please provide an explanation for why AVR-PikE has a much weaker affinity with HMA than AVR-PikD.

First, although human SP1 binds primarily to the GC box, it also recognizes the ancestral GA box consensus, although at much weaker affinity (Letovsky and Dynan 1989; Wierstra 2008).

These compounds bind to XIAP, however, with much weaker affinities.

MNK and WLN each have six MBDs, but not all form detectable complexes with HAH1 in the presence of Cu(i), whilst MNK3 has much weaker affinities for HAH1 (ref. 15) and Cu(i).

Both genistein and daidzein have much weaker affinities than does 17β-estradiol for the rat ERs: genistein binds 3- and 100-fold weaker, and daidzein binds 60- and 1,000-fold 1,000-foldrat ER-β and ER-α, respectively (Boue et al. 2003; Casanova et al. 1999).

In addition, sugars (except imino sugars) bind hSGLT3 with much weaker apparent affinity than hSGLT1 [4].

Presumably, it is due to its much weaker binding affinity (1.4 µM) than BDNF (Kd ∼10−10 M).