Sentence examples for considerably lower affinity from inspiring English sources

To determine if TCR affinity influences the onset of EAE, we identified and cloned a TCR that has considerably lower affinity for the Ac1-11 MBpeptidede presented by I-Au as compared to a previously published TCR [14].

ERβ-503 has an 18 amino acid residue in frame insertion into the LBD, and has a considerably lower affinity for E2 than ERβ-485.

In addition, GST-AS protein showed considerably lower affinity for acetazolamine, a sulphonamide inhibitor of carbonic anhydrases: Ki WT=14 n M vs Ki AS=110 n M.

As vortioxetine has a considerably lower affinity for rat, compared with human, 5-HT1A recepTable(Table 2011), combined treatments with flesinoxan (2.5 mg·kg−1) were included to mimic 5-HT1A occupancy in clinical settings.

However, despite its considerably lower affinity for CEA (Kd, 10 n M vs 20 p M), ghPR1A3 was found to be equally effective at prolonging survival when compared with SM3E.

Chd1 proteins from which the SANT-SLIDE domains have been ablated by mutation or deletion have considerably lower affinity for DNA or nucleosomes (Grüne et al., 2003; Ryan et al., 2011).

Cytochromes bo′ and bd-II also have considerably lower affinities for oxygen than bd-I.

Thus, as a hormonal ligand, while E4 has considerably lower binding affinity for ERα than E2, it forms a complex with this receptor that binds to a key coactivator protein, SRC3, almost as well as does the complex with E2.

The mutations E77A, R159E, K161E and N191R slightly decreased the nucleotide binding affinity (Additional file 6) but it is unlikely that this caused the loss of oligomerisation because the G4-motif mutant, Irga6-D186N, with a considerably lower binding affinity for guanine nucleotides, oligomerised relatively efficiently in the presence of GTP (see below).

The GluN2B affinity of the cis-configured 3-benzazepin-1-ol cis-4a with a 4-phenylbutyl side chain (Ki = 252 nM) is considerably lower than the GluN2B affinity of (R,R -2 (Ki = 17 nM) indicating the impoR,R -2 of the phenolic OH moiety for the interaction with the receptor protein.

However, the TR binding affinity of T4 is considerably lower than that for T3.