Sentence examples for substantially lower affinity from inspiring English sources

Coro1A has a substantially lower affinity for F-actin than Coro1B, but it was able to compete with Coro1B for binding.

Importantly, in vitro these agents are characterised by potent growth inhibitory activity in moderately and highly docetaxel-resistant cell lines, most probably based upon a substantially lower affinity for ABCB1.

Because free kinesin heads in solution have a high affinity for ADP, whereas MT-bound heads exhibit a substantially lower affinity, the release of mantADP from kinesin heads serves as a proxy for the binding of free heads to MTs (Hackney, 1988, 1994, 2002; Gilbert et al., 1995; Hackney et al., 2003; Clancy et al., 2011).

PG-116800 has high affinity for MMP-2, -3, -8, -9, -13, and -14, the therapeutic targets, while having substantially lower affinity for MMP-1 and -7, both of which were thought to be implicated in the pathogenesis of musculoskeletal toxicity [ 25].

This may be the reason for different subsequent signal transduction and the substantially lower affinity of VEGF-B compared to VEGF-A, which in turn provides a simple explanation of our observation that iBREC proliferation induced by VEGF-A was not notably affected by equimolar amounts of VEGF-B.

The alpha-1 isoform has substantially lower affinity (Kd in the μM range) for the specific Na,K-ATPase inhibitor, ouabain, than is required to inhibit the alpha-2 and −3 Na,K-ATPase (Kd in the nM range), consistent with the demonstration that 1 mM ouabain is required to retain sodium in the CP [ 30].

NY18 is an intermediate between SC18 and AV18 since it shows a mixed human/avian receptor binding, albeit at substantially lower affinities than SC18 (for the human receptor) and AV18 (for the avian receptor).

Interestingly, Ala substitution of the Cys residues in the CACP stretch manifested in substantially lower heme affinity than wild-type p53.

NY18 bound to both avian and human receptors with a binding affinity substantially lower than that observed for AV18 and SC18.

The glycoengineered variant antibodies have been shown to have substantially improved binding to the lower affinity Fc γRIIIa receptor polymorphic variants, which have phenylalanine instead of valine at amino acid position 158 (Ferrara et al, 2006).

Furthermore, the affinity for coenzymes is substantially lower than that of the wt protein (Michaelis constant KM for p, 25-fold greater)." In the above example, the first impact the increase of the turnover number can be grounded to the mutation N249Y.