Sentence examples for modulation of canonical from inspiring English sources

This plastic configuration has also been exploited as a scaffold to support the modulation of canonical MAPK and AKT modules.

The molecular mechanism of Vent-mediated modulation of canonical Wnt signaling thus remains unclear.

Similarly, temporal modulation of canonical WNT signaling in human pluripotent stem cells results in robust cardiomyocyte differentiation (Lian et al. 2013).

We conclude that the tumour suppressor functions of Dab2 involve modulation of canonical Wnt signalling by regulating the endocytic fate of the LRP6 receptor.

The protective role of dietary fibers and their breakdown product butyrate against colorectal cancer could be determined by a modulation of canonical Wnt signaling, a pathway constitutively activated in the majority of colorectal cancers [ 17].

These data support the concept that modulation of canonical Wnt signaling could represent a novel therapeutic target to influence the survival of non-transformed stem cells and possibly also of tumor stem cells in response to DNA-damaging agents.

To study the effect of VANGL2 modulation on canonical WNT/ β-catenin signaling, we determined β-catenin levels by immunofluorescence microscopy and analysed β-catenin/TCF-dependent transcription in luciferase reporter assays before and after VANGL2 overexpression in SW480.

Loss of muscle mass in sarcopenia has been linked to the modulation of the canonical (Smad-dependent) and non-canonical (Smad-independent) TGF-β signaling cascades [ 3].

To investigate the effects of familiarity on the parametric modulation of the canonical hemodynamic response function (HRF), a parametric regressor modelling familiarity was constructed, based on the familiarity judgments for each melody excerpt.

Thermal stability of proteins has been mainly studied in thermophilic microorganisms and the overall conclusion from such studies is that the stability is mediated by modulation of the canonical forces such as electrostatic and hydrophobic interactions found in all proteins [10].

We conclude that time-controlled modulation of the canonical Wnt pathway by Dkk1 or Wnt8 induction during somitogenesis modifies somite length, starting eight somites phs, without affecting embryonic elongation.