This function is important in the modulation of synaptic transmission.
This is the first demonstration of cholinergic modulation of synaptic plasticity over the time-course of days.
Accordingly, our findings indicate that neuroprotective properties of MNA are linked to modulation of synaptic activity through multiple mechanisms.
Recent studies have confirmed that the modulation of synaptic efficacy affects emergent behaviour of brain cells assemblies.
Emerging roles of Wnts include the differentiation of synaptic specializations, microtubule dynamics, architecture of synaptic protein organization, modulation of synaptic efficacy and regulation of gene expression.
Together, our results provide compelling evidence for an in vivo role of neurexins in the modulation of synaptic architecture and adhesive interactions between pre- and postsynaptic compartments.
The elaborate morphology, nonlinear membrane mechanisms and spatiotemporally varying synaptic activation patterns of dendrites complicate the expression, compartmentalization and modulation of synaptic plasticity.
Some studies demonstrated that amygdala also involved the migraine pain modulation, such as the modulation of synaptic transmission by CSD [9] and the PAG network [10] and chronic migraine.
In fact such experiments can also provide phenomenological evidence for the modulation of synaptic plasticity by the somatic potential, or at least by a low-pass filtered version thereof.
In the presynaptic neuron, the uptake completes the stock whereas the uptake by the astrocyte triggers a cascade of reactions linked with the modulation of synaptic transmission (differentially according to the type of neurotransmitters) and the hemodynamics.
A number of studies show that NO regulates neurotransmitter release and different aspects of synaptic dynamics, such as differentiation of synaptic specializations, microtubule dynamics, architecture of synaptic protein organization, and modulation of synaptic efficacy.
