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The corresponding modulation of central frequency is about 24%.
The pathophysiology of migraine involves many different mechanisms including modulation of central and peripheral pain structures and release of vasoactive peptides.
The results of this study indicate that modulation of central histidine residue is important for designing analogues which were selective agonist at TRH receptor subtypes.
Transcranial electrical stimulation (tES), including transcranial direct and alternating current stimulation (tDCS, tACS) are non-invasive brain stimulation techniques increasingly used for modulation of central nervous system excitability in humans.
This network-wide strategy is in contrast with traditional metabolic engineering approaches, that entail direct modification of the pathway(s) at stake, and opens new avenues for the targeted modulation of central catabolic pathways at the transcriptional level.
Targeting peripheral CGRP may reduce or prevent the phenomenon (i.e. vasodilation) that has been advocated as a mechanism of headache and associated symptoms, whereas whether long-term inhibition of CGRP outside of the blood-brain barrier induces modulation of central pathways remains unknown.
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Overall, our findings suggest that maternal HFD influence adult depressive disorder response to stressful challenge, through the modulation of endogenous central CGRP signaling and HPA-regulatory components.
Histamine H3 receptor is a G protein-coupled receptor whose activation inhibits the synthesis and release of histamine and other neurotransmitters from nerve endings and is involved in the modulation of different central nervous system functions.
If one wanted to maintain that our experimental conditions led to a central source of priming (which the MCE for novel primes suggests), thereby excluding a peripheral source, then one would need to argue that the earlier and larger priming effect for the repeated primes was due to a consciously induced modulation of the central representations for the repeated stimuli.
Dopamine is a major neurotransmitter, and its modulation of the central nervous system accordingly affects diverse functions and behaviours [ 30].
This enabled the effective modulation of two central growth control pathways resulting in the phenotypic outcome of cell cycle reentry in postmitotic islet cells.
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