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One hypothesized mechanism is through modulation of microtubule stability.
Modulation of microtubule assembly is of great interest in the development of new cancer treatments [50], [52] [56].
Finally, we checked whether a modulation of microtubule dynamics could modify the pathological phenotype of Sp Δ/Δ cortical neurons.
Our analysis also reveals that a modulation of microtubule dynamics by microtubule-targeting drugs rescues the mutant phenotype of cortical neurons.
In conclusion, our analysis shows that a modulation of microtubule dynamics using different microtubule-targeting drugs can efficiently reduce the occurrence of axonal swellings in mammalian spastin-deficient neurons.
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Expression of Epstein-Barr virus's LMP-1 protein or SV40's large T antigen causes formation of aberrant microtubule structures via the respective modulation of microtubule-stabilizing proteins RASSF1 A [70] and TACC2 [39].
Many of these signaling events have been shown to be important for post-binding virus entry steps, for example modulation of microtubules, movement of virus in the cytoplasm and nuclear delivery of viral DNA [48].
Modulation of microtubules via histone deacetylase inhibitors has improved transfection by 10-fold.
Several genes that underlie LIS are directly or indirectly associated with modulation of microtubules, which are cytoskeletal elements involved in key cellular processes including mitosis, cytokinesis, vesicle transport, and neuronal migration.
But, we cannot exclude another possibility of the direct modulation of stable microtubules by Spastin.
Instead, this variability reveals a cell autonomous control of the microtubule array that could include modulation of the KATANIN-dependent severing of intersecting microtubules [ 46] and the dynamic remodeling of the inner-most network of cellulose microfibrils that determine the elastic properties of the wall.
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modulation of enzymatic
modulation of frontal
modulation of intracellular
modulation of nucleotide
modulation of programmed
modulation of secondary
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modulation of synaptic
modulation of individual
modulation of canonical
modulation of gastric
modulation of important
modulation of lipid
modulation of phagosome
modulation of corticospinal
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