Sentence examples for modulate promoter activity from inspiring English sources

In presence of NRL, no other transcription factor could significantly modulate promoter activity.

The ParR protein binds to parC and thereby modulate promoter activity [17].

In cells, formation of Z-DNA is induced by negative supercoiling, generated by moving RNA-polymerases during transcription, and can modulate promoter activity probably by alternating the local architecture of promoter regions and nucleosome positioning [ 23, 24].

Bacterial genes are differentially expressed during the cell cycle in response to a wide variety of signals that modulate promoter activity and in some cases it may be interesting, however, to express specific genes constitutively and at a specific level.

As promoter regions are often insufficient to maintain correct messenger RNA (mRNA) expression levels in appropriate cells and in response to appropriate cues, cis-regulatory elements (CREs) are frequently required to modulate promoter activity so that transcriptional levels appropriate to health are maintained (28 31).

We previously demonstrated that a polymorphic GAn microsatellite in the mouse Fli1 promoter modulates promoter activity in a T cell line and is evolutionarily conserved [ 7].

Recently, a GAn polymorphic microsatellite was characterized in the mouse Fli1 promoter that modulates promoter activity and is truncated in two lupus mouse models compared to non-autoimmune prone mice.

Functional variants in TERT have been shown to affect telomerase expression through modulating promoter activity (Beesley et al, 2011), and such a mechanism offers a possible explanation for how a putative functional variant at TERT affects CRC risk (Aisner, 2002).

Although the GAn microsatellite in the mouse and human promoters is not required for promoter activity in vitro [ 7, 8], varying the length of the microsatellite in the mouse promoter modulated promoter activity in T cells with the length of the microsatellite being inversely proportional to promoter activity [ 7].

To test whether the predicted half ERE sites are functional, we cloned the promoters of the four genes (Additional file 1: Figure S1; human promoters were used) into luciferase vectors and then assayed their capacity of modulating promoter activity in response to estradiol treatment of the transfected HEK293T cells.

These transgenic or viral based strategies, however, involve integration of the exogenous DNA into random genomic loci that can modulate the promoter activity, depending on the epigenetic state around the integration site.