Sentence examples for modulate p53 activity from inspiring English sources

Interestingly, these two stimuli induce different p53 modifications [19] [21], raising the possibility that the activating signal may modulate p53 activity in a qualitative manner by directing p53 to different promoters [22].

It could be argued that the observed NF- κB activation might in turn modulate p53 activity as a negative feedback loop.

To mediate these functions, the p53 protein must be activated by posttranslational modifications, which modulate p53 activity and interactions.

There are multiple mechanisms through which ATM can modulate p53 activity.

ING1 has been shown to modulate p53 activity and its downstream effectors, p21WAF1 and Bax by acetylation and stabilization [30].

First, certain collateral signals might directly modulate p53 activity by changing the conformation of p53 or its association with various coactivators, perhaps leading to the expression of different subsets of p53 target genes.

It is thus possible that mutant WT1 proteins modulate p53 activities in Wilms tumour cells.

Moreover, E2F1 could modulate mTORC1 activity through the modulation of PLD.

G1 cyclin Cln1/2 is shown to modulate Ste20 activity of MAPK pathway for a function independent of transcriptional activation of FLO11 [43].

Cholesterol binding appears to modulate CD81 activity in cells, suggesting a potential mechanism for regulation of tetraspanin function.

In vivo pharmacological effects have been used as indirect proxies for AM-1241 biotransformation processes that could modulate CB2 activity.