Sentence examples for modulate channel activity from inspiring English sources

A physiological implication of our findings is the possibility that protamine mimics the action of positively charged peptide motifs, present in the vicinity of the RyR2 channels in cells which might modulate channel activity (activation and deactivation).

The perturbation at R243W remarkably hampers the ability of KCNE1 to properly modulate channel activity.

This loop thus can represent an ideal and CLC-K specific target for extracellular ligands able to modulate channel activity.

Our results show that M3R and NALCN are necessary for recapitulating the native current in recombinant systems, but also suggest that further proteins probably modulate channel activity and/or the level of channel expression at the plasma membrane in native systems.

19– 21 CFTR-mediated chloride secretion across epithelial cells is controlled by both modulating channel activity and regulating the total number of CFTR channels in the membrane.

Our studies also suggest that growth factor receptor-bound protein 14 (Grb14), a Ras-associating (RA) domain-containing protein, binds to CNGA1 and modulates channel activity [ 10].

Most notably, suppression of ICl by OAA is consistent with a role for this dicarboxylic acid in modulating channel activity for a diurnal cycle of Mal accumulation and release that parallels the cycle of stomatal opening and closing.

In addition to the various signaling pathways that may modulate the channel activity, ion channel activation also involves subunit assembly/disassembly, trafficking, insertion and endocytosis of functional channel to/from the plasma membrane.

However, the inability of 4-AP to prevent LY83583 from causing constriction in PA also refutes the supposition that ROS differentially modulate KV channel activity in PA (inhibition) and MA (activation).

In particular, products of lipoxygenase have been demonstrated to directly modulate TRPV1 channel activity [26].

Thus, phosphorylation is probably a common cellular mechanism to modulate HCN channel activity.