Sentence examples for modulate telomerase activity from inspiring English sources

This emphasizes the need for therapeutics that can modulate telomerase activity in vivo.

In vitro studies using purified coilin demonstrate that coilin can specifically process scaRNA 9. Given that coilin associates with hTERC/hTR, and may possibly play a role in its processing, we also examined if coilin is associated with telomerase or can modulate telomerase activity.

The role of PPARγ in modulating telomerase activity in breast cancer cells has not been studied and may have therapeutic potential.

The interplay of this set of proteins in modulating telomerase activity and telomere length is incompletely understood, but it is clear that post-translational modifications of telomeric proteins play an important role.

In view of our findings we could conjecture that telomerase activity could be modulated by estrogen receptors, which also might regulate the expression of bcl-2.

Alternatively, it is possible that the CST complex exerts a sort of 'default' repressive action on telomerase activity that is not modulated by repeat array length.

Another in vitro study found that, in the context of Stn1p and Ten1p, Hsp82p can modulate Cdc13p DNA binding and thereby its effects on telomerase activity (DeZwaan et al. 2009).

Anti-cancer drugs can also block the cell cycle and inhibit cell growth, while activating caspase cascades and modulating telomerase expression and activity [ 23– 25].

In summary, it appears that regulating telomerase activity appropriately in ESCs is critically important for maintaining ESC pluripotency and modulating their differentiation.

Telomerase activity is associated with longer telomeres.

Exercise may be affecting telomerase activity and not telomeres directly.