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AGEs modulate cellular function mediated through binding of their specific acceptor molecules.
They also generate reactive oxygen species which modulate cellular function and can induce inflammatory processes (Krieglstein and Granger 2001; Basta et al. 2002; Ramasamy et al. 2005).
Given their significant differences from conotoxins, teretoxins may have novel molecular targets, thus identifying new mechanisms to modulate cellular function in the discovery and development of biomedical therapeutic agents.
However, recent studies in diverse organisms have uncovered a unique process of retrograde regulation by which mitochondria exert specific effects on nuclear function and thereby modulate cellular function under normal and pathophysiological conditions.
We suggest specific biochemical mechanisms by which disordered segments may influence degradation rates, how these changes might modulate cellular function and phenotype, and how natural variation in the length and position of intrinsically disordered protein regions may contribute to the evolution of protein half-life.
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The aim is to exploit the nano-scale functional and material characteristics of natural bone in order to modulate cellular functions for optimal bone repair in bone graft systems.
Importantly, the overall composition of the ECM, especially the relative amounts of the many types of collagens, which represent the most abundant ECM molecules and which centrally modulate cellular functions and physiological processes, changes dramatically during fibrosis progression.
Structural motifs in naturally occurring RNAs and RNPs can be employed as new molecular parts for synthetic biology to facilitate the development of novel devices and systems that modulate cellular functions.
This powerful oxidant has been reported to modulate cellular functions through the nitration of tyrosine residues.
Furthermore, chlamydiae modulate cellular functions such as apoptotic programs and immune response [6], [7].
Additionally, MHCI molecules can dissociate, leaving free heavy chains on the cell surface which can associate in cis with other free heavy chains and receptors on the same cell surface and modulate cellular functions (reviewed in [49]).
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modulate cellular morphology
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modulate cellular host
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