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In cell culture expression systems TRPC4 and 5 channels function to modulate cellular excitability, neuronal growth and axon guidance, and regulation of Ca2+ homeostasis [4], [2], [10],[10].
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The canonical transient receptor potential (TRPC) family of Ca 2+ permeable, non-selective cation channels is abundantly expressed throughout the brain, and plays a pivotal role in modulating cellular excitability.
Activation of the channels induces long-lasting (tonic) currents in neurons that modulate the cellular excitability [ 17, 29, 30].
In neurosecretory cells, rising calcium levels control cellular excitability, modulate their firing patterns, and lead to transmitter release.
Photocontrol of endogenous ion channels and cellular excitability.
Each domain interacts with various effectors to modulate cellular functions.
Meinert, C. et al. Tailoring hydrogel surface properties to modulate cellular response to shear loading.
Thus, Cl− exchange mechanisms seem to play a more important role in maintaining cellular excitability than taken into account so far.
Optogenetic tools presently enable scientists to drive changes in cellular excitability, intracellular signaling, gene expression, and receptor function.
Broad questions that her lab is addressing are: How do viruses effectively modulate cellular pathways?
Estrogens may interfere with cellular excitability or cerebral vessels.
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