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In the present work, we investigated the capacity of a targeted therapy directed against IL-6 to modulate cellular resistance to radiotherapy and chemotherapy.
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In summary, our results emphasize the interplay between JC15 and CypD in regulation of MPT, thereby modulating cellular resistance to cisplatin treatment.
For example, the anti-recombinogenic effects of the BLM helicase, mutated in Bloom's Syndrome, or the p53 tumour suppressor are not thought to significantly modulate cellular radiation resistance (Dahm-Daphi, 2000; Thompson and Schild, 2001; Böhnke et al, 2004).
Our results illustrate that a wide-range of mutations can modulate the activity of many cellular resistance processes and demonstrate that E. coli has a large mutational target size for increasing antibiotic tolerance.
Emerging evidence indicates that ceramide glycosylation is a newly identified mechanism promoting cellular resistance; however, whether GCS directly modulates tumor response to chemotherapy remains to be clarified.
Each domain interacts with various effectors to modulate cellular functions.
Meinert, C. et al. Tailoring hydrogel surface properties to modulate cellular response to shear loading.
Broad questions that her lab is addressing are: How do viruses effectively modulate cellular pathways?
Peptide inhibitors disrupt the serotonin 5-HT2C receptor interaction with phosphatase and tensin homolog to allosterically modulate cellular signaling and behavior.
In optogenetics, light-activated proteins are used to monitor and modulate cellular behaviour with light.
Our results inform the rational design of receptors that integrate multiple signals to modulate cellular behavior.
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