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The MAPKs are intracellular enzymes activated by extracellular cues and in turn phosphorylate effector proteins to modulate cellular activity and function.
As an acoustic energy source, US has become increasingly appreciated over the past decade for its ability to non-invasively modulate cellular activity including neuronal activity.
These engineered receptors modulate cellular activity by acting on G protein coupled signaling cascades and in this review we pay particular attention to how this slower-onset modulation preferentially regulates behaviors that develop over time.
Cholinergic neurons with cell bodies located in the basal forebrain modulate cellular activity throughout the cerebral cortex, with wide-ranging physiologic effects.
In contrast, some lipid peroxidation products modulate cellular activity through irreversible covalent modification of nucleophilic amino acid residues on proteins [ 15, 30].
Functional cross-talk between the receptor signaling pathways as well as novel pharmacological and/or functional properties will provide evidence for the mechanism by which receptor-receptor-interactions modulate cellular activity [ 218].
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However, in order to achieve successful regeneration of tissues or organs based on the tissue engineering concept, several critical elements should be deliberately considered including biomaterial scaffolds that serve as a mechanical support for cell growth, progenitor cells that can be differentiated into specific cell types, and inductive growth factors that can modulate cellular activities.
However, they are transcription factors, and as such cannot directly modulate cellular activities.
Once in the nucleus, these growth factors might directly modulate cellular activities [ 39].
Like other miRNAs, miR-146a can modulate cellular activities, such as cell proliferation, differentiation, and migration, by targeting mRNAs encoding specific proteins.
These changes in the structure and composition of ECM progressively alter the biological and mechanical microenvironments that significantly modulate cellular activities as described later in this review.
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modulate cellular morphology
modulate cellular resistance
modulate cellular communication
modulate cellular behaviour
modulate cellular migration
modulate cellular responsiveness
modulate cellular uptake
modulate oscillatory activity
modulate cellular host
modulate cellular excitability
modulate cellular longevity
modulate cellular response
modulate cellular signal
modulate cellular function
modulate enzyme activity
modulate cellular senescence
modulate mTOR activity
modulate cellular behavior
modulate cellular differentiation
modulate cellular proliferation
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