Sentence examples for modulate enzyme activity from inspiring English sources

These scFvs could thus be used as probes for the active site of PLAP and to modulate enzyme activity.

Functioning as an activator, ISRIB joins the still sparsely populated group of unnatural small molecule enzyme activators, while the vast majority of synthetic small molecules that modulate enzyme activity are inhibitors (Wiseman et al., 2010; Zorn and Wells, 2010; Wang et al., 2014).

Gopal et al. [ 28] demonstrated that ions of the same charge as the ions in the active site can replace them and in this way modulate enzyme activity.

Furthermore, ionic compounds can modulate enzyme activity.

The identification of haplotypes which modulate enzyme activity to a greater degree than a single polymorphism might explain the sometimes contradictory results of previous genetic association studies with other common disease[59], [60].

H2O2 can modulate enzyme activity by several differing mechanisms.

The attachment of SUMO moieties to their substrate targets regulates many relevant physiological processes by modulating enzyme activity, activating transcription factors (TFs), shifting protein subcellular localizations, and eventually, determining their substrate fate.

The selection strategy could generate specific anti-enzyme antibodies to PLAP that can potentially be used for targeting, for modulating enzyme activity in in vitro and in vivo and as probes for the active site.

Like other imidazoline receptor modulators, CR4056 is a functional and reversible inhibitor of MAO-A, because it modulates enzyme activity through allosteric I2 sites present in a discrete population of MAO proteins (Carpéné et al., 1995; Tesson et al., 1995; Ferrari et al., 2011).

Reactive oxygen species derived from polymorphs can indirectly affect gene expression by, for example, modulating enzyme activity and promoting changes in transcription factor binding capacity.

A GSM compound, capable of modulating enzyme activity to selectively lower Aβ42 levels, without inhibiting the enzymatic machinery or reducing the absolute levels of Aβ peptides, would likely circumvent many if not all of the major obstacles that attended the development of GSIs.