Sentence examples for modifiers of protein from inspiring English sources

It will be worthwhile to perform such studies for modifiers of protein misfolding in order to identify gene networks that modify disease pathology.

Post-translational modifications are central modifiers of protein activity [20], [21].

Given the apparent importance of these regions for protein interaction, this implies that modifiers of protein aggregation are likely to be found within the set of AR and Htt interacting proteins.

The inactivity of SERF1a on nonamyloid aggregation is in clear-cut contrast to general modifiers of protein aggregation, such as molecular chaperones, the autophagy pathway or the proteasome.

The selectivity of SERF1a for amyloid aggregation distinguishes this protein from other general modifiers of protein aggregation and explains the unique chaperone-, proteandme-, autophagy-independentdent properties of the SERF proteins observed in cellular systems (van Ham et al., 2010).

The degree of mRNA abundance is influenced by multiple factors, and does not provide any direct information about gene end products (proteins), nor post-translational modifiers of protein function, such as phosphorylation or glycation.

PEG hydrogels are widely used in FDA approved therapeutic products as covalent modifiers of proteins and lipids [ 62].

A diverse collection of enzymatic and reversible modifiers of proteins exists, but for the purpose of this review we will concentrate on phosphorylation, glycosylation (N- and O-linked), lysine acetylation, sumoylation (via addition of small ubiquitin-like modifier (SUMO)) and citrullination (or deimination).

Recent screenings in C. elegans identified the evolutionarily conserved protein MOAG-4/SERF1-2 as a modifier of protein aggregation during ageing.

The concept that proteotoxicity of expanded PABPN1 is caused by altered protein networking has important implications for the development of novel therapeutic strategies, such as druggable modifiers of altered protein function [45].

Phenolic phytochemicals are particularly promiscuous modifiers of membrane protein function, suggesting that some of their actions may be due to a common, membrane bilayer-mediated mechanism.