Sentence examples for modifiers of channel from inspiring English sources

When expressed as heterotetramers with, for example, Kv2.1, the "silent" subunits become modifiers of channel function [50], [51], [52].

Because of the diversity of functions and ion channel types there is a great interest in developing methods to identify and analyze modifiers of ion channel function [2] [5].

Because of the high level of conservation of the amino acid sequences among the eight mammalian TMC proteins, we speculate that other TMC proteins may as well be modifiers of ion channels or transporters.

The further development of genetic approaches such as those described here as well as novel technologies that facilitate the characterization of ion channel-blocker interactions [17] should provide new avenues for the discovery of ion channel modifiers for channels that presently lack pharmacologies.

This combined system allows studying the activity of ion channels and pores and would facilitate high-throughput screening of channel activity modifiers and thus would be a valuable tool for developing therapeutics for channelopathies.

Several genes have been associated with type 2 diabetes susceptibility or manifestation, including genes encoding receptors, transcription factors, cell cycle-associated proteins, modifiers of signal transduction, ion channels and others [ 2– 4].

Functional complementation of potassium transport deficient Saccharomyces cerevisiae strains lacking the Trk1p and Trk2p transporters, such as SGY1528, has been a fruitful system for the study of a variety of eukaryotic and bacterial potassium channels and the characterization of channel interactions with chemical modifiers.

This is more similar to rectification of channel conductance induced by other polycations than to the action of selective conductance modifiers (ryanoids, imperatoxin).

We speculate that the TMC proteins constitute a novel group of ion channels, transporters, or modifiers of such.

This organization could allow for the encoding of a broader range of stimuli and places Trp channels as critical modifiers of incidence detection.

Fear of channel conflict.