Through screening, zebrafish have a unique role in the identification of chemical and genetic modifiers of drug-induced hearing loss.
Despite this, CLCR remains a common modifier of drug dosing in clinical practice, with recent data suggesting important pharmacokinetic [ 11, 12], and clinical [ 21] implications.
Polyethylene glycol (PEG) is a component that has been widely used as a modifier of drugs and has been approved by the food and drug administration of United States of America.
In addition, it is important to identify extrinsic and intrinsic modifiers of study drug exposure in the liver, as well as factors which predict increased susceptibility to hepatotoxicity by the study drug at lower doses.
Other projects currently ongoing include gain-of-function ORF screens to identify (1) modifiers of chemotherapeutic drug response and (2) regulators of signaling pathways commonly activated during tumorigenesis.
Because physiology depends on disease state, we hypothesized that the effects of another common modifier of physiology, drugs, would be apparent when visualizing physiological correlation networks and comparing the cases of the drugs being given or not.
For formulations without any release-modifier, the extent and rate of drug release at pH 6.8 was much higher than that at pH 1.0.
LSD1 is overexpressed in various cancers, and recent researches showed that this epigenetic modifier is associated with the development of drug resistance.
To date a number of potential radiosensitising agents such as metallotexaphyrins, synthetic allosteric modifiers of haemoglobin or other chemotherapeutic drugs have been used without a demonstrable improvement in survival of patients with BM (Komarnicky et al, 1991; Phillips et al, 1995; Mehta et al, 2003).
