Sentence examples for modifiers of toxicity from inspiring English sources

We have been using these screens to identify genetic modifiers of toxicity associated with the accumulation of aggregation-prone human neurodegenerative disease proteins.

Indeed, the recent finding that Htt-interacting proteins are enriched for genetic modifiers of toxicity is consistent with this idea [38].

Using libraries of genetically altered transposon (P-element) insertion strains, additional modifiers of toxicity of polyglutamine proteins have been screened for.

Enhancers were scored when compared with the GMR-GAL4/+; gl-tau/+ control, ensuring that only the most robust and reliable modifiers of toxicity were included.

Modifiers found in the mutant SCA1 (82Q) flies have been tested in an Htt-128Q fly model, revealing common and specific modifiers of toxicity (Branco et al, 2008).

The modifiers fall into three classes: (i) modifiers of toxicity in only one model, (ii) modifiers that enhance or suppress toxicity in both models and (iii) modifiers that function as both enhancers and suppressors, depending on the background.

Furthermore, the observation of muscleblind (mbl), another RNA-binding protein, as a modifier of toxicity has led to the discovery that the SCA3 transcript itself is toxic (Li et al, 2008).

We further validated this system by identifying known and previously unidentified GIs between modifiers of ricin toxicity.

We recently performed a genetic screen in yeast for modifiers of PR toxicity and identified suppressors and enhancers, many of which function in nucleocytoplasmic transport.

We uncovered potent modifiers of DPR toxicity whose gene products function in nucleocytoplasmic transport, the endoplasmic reticulum (ER), proteasome, RNA-processing pathways, and chromatin modification.

We performed two unbiased screens in Saccharomyces cerevisiae and identified potent modifiers of DPR toxicity, including karyopherins and effectors of Ran-mediated nucleocytoplasmic transport, providing insight into potential disease mechanisms and therapeutic targets.