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Other factors that emerged as possible modifiers of outcome were voluptuary habits.
Co-removal of dGALK, and sgl overexpression, both are strong genetic modifiers of outcome in this CG model.
Genetic polymorphisms are candidate prognostic markers because of their variability among different individuals and their potential role as the biological modifiers of outcome risk.
21 We also did meta-regression using "xtmelogit" regression to identify the influence of potential modifiers of outcome including parity, maternal age, and ethnicity on the relation between chronic hypertension and subsequent outcome.
Of note, the oxidant and antioxidant modifiers of acute outcome described here represent the first modifiers of outcome in GALT deficiency that do not appear to work by either preventing the synthesis of gal-1P or promoting its catabolism (Wierenga et al., 2008; Boxer et al., 2010; Tang et al., 2011).
Similar(55)
The current results define a new genetic disease modifier of outcome after cardiac ischemia that is specific for diabetes and suggests a biologic mechanism for the previously described PPARA intronic SNP.
Taken together, these findings show that concomitant overexpression of sgl is a strong positive modifier of outcome in this CG model.
However, there is controversy regarding galactose restriction in preventing chronic complications (Hughes et al., 2009; Jumbo-Lucioni et al., 2012), particularly in preventing CG neurological symptoms, and whether supplementation or restriction are important environmental modifiers of disease outcome.
Because breast-feeding is an important modifier of neurodevelopmental outcome, not controlling for its duration could be a limitation in the Gesell Developmental score (GDS) outcomes related to Hg.
We hypothesized that AR CAG allele length is a modifier of clinical outcome in BRCA1/2 mutation positive women with ovarian cancer.
Because exposure to dietary galactose is a well-recognized modifier of acute outcome in CG (Jumbo-Lucioni et al., 2013), we next characterized locomotion and NMJ structural defects with galactose dietary supplementation.
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determinants of outcome
determinant of outcome
modifiers of breast
modifiers of channel
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modifiers of disease
modifiers of lung
modifiers of protein
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modifiers of recombination
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