Sentence examples for modifiers of gene from inspiring English sources
RNA also offers an interesting raw material for the design or genetic selection of modifiers of gene expression.
Small non-coding RNAs, particularly miRNAs, however, have emerged as powerful regulators and modifiers of gene expression through inhibition of mRNA translation [48], which has implications for hematopoiesis and erythropoiesis [49, 50], particularly in the distinct miRNA expression patterns in SCD patients [51] and the severity of anaemia [52].
miRNAs are novel, highly conserved modifiers of gene expression that are responsive to various stressors including free radical stress, DNA damage, and ionizing radiation.
Furthermore, steroids are potent modifiers of gene expression [35] but it remains to be investigated how a particular steroid would be able to affect a specific subset of genes, as would be required in order to explain the relation between DE of specific genes in the two generations.
Our results further support the notion that miRNAs are important modifiers of gene expression program in cardiovascular diseases.
A facilitating step towards understanding the basis for gene expression variability is associating genome wide transcription patterns with potential cis modifiers of gene expression.
We have previously shown that GRPR activation results in the up-regulation of HP1β, an epigenetic modifier of gene transcription.
Since HP1β is an epigenetic modifier of gene transcription, we next determined which genes had altered expression as a result of both GRPR activation and HP1β expression.
This article explores the hypothesis that, for transgenerationally inherited chromatin structures, " genotype predisposes epitype", and that epitype functions as a modifier of gene expression within the classical central dogma of molecular biology.
> Since HP1β is an epigenetic modifier of gene transcription, we performed chromatin immunoprecipitation against genomic DNA obtained from GRP/GRPR-expressing Caco-2 cells in order to identify where this protein was binding in the genome.
Although PB was an effective modifier of gene expression in this study of murine liver, only about 40 genes of the total 1600 on ToxArray™ might have been categorized by RT-PCR as significant responders, predicting from the existing microarray data and the observed frequencies of RT-PCR confirmation.
