Sentence examples for mediating loss of from inspiring English sources

Due to the complexity of the structure of oral mucosal biofilms [9], transcriptional deregulation of a single C. albicans gene is unlikely to be responsible for mediating loss of the mucosal biofilm phenotype in the bcr1/bcr1 mutant.

We employed a reverse genetic approach using the Arabidopsis T-DNA SALK lines mediating loss of function of AN gene to examine new an-knockout phenotypes.

We employed a reverse genetic approach using the Arabidopsis T-DNA SALK lines mediating loss of function of CURVY1 gene to examine curvy1-knockout phenotypes.

However, there was an increase in CCBE1 mRNA in the CCBE1 methylated cell lines A2780, OV90 and TOV21G cell lines after 5-AZA treatment as compared with untreated cells, supporting hypermethylation of the CCBE1 promoter as one mechanism mediating loss of expression.

Since LATS1/2 and YAP/TAZ have opposing effects on drug response and LATS1/2 can inhibit YAP/TAZ function through phosphorylation [ 190– 192], we propose that YAP/TAZ-TEAD-Cyr61/CTGF is a novel signalling pathway mediating loss-of-LATS-induced drug resistance in the treatment of human cancers.

Short hairpin RNA (shRNA) mediated loss-of-function screens in mammalian cells are powerful tools for the discovery of novel gene functions.

To explore the wider gene network associated with Dom action, we used RNAi directed against domino (dom ) to mediate loss-of-function at the wing margin, a tissue that is readily scored for phenotypic changes.

Indeed, DNA methylation-mediated loss of expression has been shown to cause functional ablation of hemizygous alleles at loss of heterozygosity (LOH) loci, encoding transcription factors (TF), e.g. MOS, TTF-1 [ 20, 21], or proteins associated with DNA repair [ 22, 23], proteolytic processing [ 24], morphogenesis [ 25], control of cell cycle, signal transduction or apoptosis [ 26].

Thus it is possible that PARIS is the predominant parkin substrate that mediates loss of DA neurons due to parkin inactivation since PARIS levels were reduced by c-Abl inhibition, but AIMP2 levels were not.

However, the molecular mechanisms that mediate loss of D2R in vivo remain unclear.

Once initiated, BAK mediates loss of the mitochondrial membrane potential that is required for oxidative phosphorylation, a reduction in cellular ATP level, and caspase independent cell death.