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On the other hand, when CD44+ cells were transplanted from the in vitro to in vivo environment triggering marked cell loss through apoptosis, a 100 fold reduction of tumor cells was able to initiate tumors at a faster rate in sequential mice generations, demonstrating the robustness of the stem cell-like subpopulation contained in the selected cells.
TH-VHLKO PHD3KO TH-VHLKO PHD3KOd higher numice of GFalsocellshowedhigherregionumbermarked cell lofs in the AM (FiGFAP+and cellsttom panels).
Compared with PD, DLB demonstrates less marked cell loss in the substantia nigra, and a relative lack of D2 receptor upregulation in the striatum [ 47].
In this study, we demonstrate that in vitro exposure of spinal motoneurons to selected statins, especially fluvastatin, resulted in marked cell loss.
In the cells with severe complex I deficiency there is evidence of marked cell loss which is entirely compatible with the neuropathological changes seen in patients with mtDNA disease.
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In post-mortem cases with Dravet syndrome, PM1/EP039 and PM3/EP099, hippocampal sclerosis controls and one control with no known neurological disease (Control 5) that had marked Purkinje cell loss, GFAP and HLA-DR-immunopositive cells were also observed in the cerebellar molecular layer.
Unlike most electrical kindling models, marked neuronal cell loss and gliosis is seen histologically in the electrical kindling model utilized by Hendriksen et al with a latent period of between 1 and 2 weeks following electrical kindling of the angular bundle and the appearance of spontaneous seizures.
For example, small clones may derive from recently induced cells or they may be associated with chance expansion and contraction through differentiation and cell loss in older early marked cells.
Dotted white lines mark cell nuclei.
Those retinas expressing wild-type tau showed marked ommatidial disorganization and cell loss (Fig. 3C), whereas S2A had a much more modest effect on retinal morphology (Fig. 3D) and resembled the driver control (Fig. 1D).
Post-mortem analysis of human HD brains shows marked widespread atrophy, with notable cell loss in the striatum and cortex (3, 4).
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marked cell shrinkage
marked cell migration
marked cell cycle
marked cell growth
marked cell proliferation
marked cell population
marked cell elongation
marked cell apoptosis
marked vision loss
marked cell line
marked cell infiltration
marked cell rounding
marked cell death
marked cell atypia
marked chlorophyll loss
marked bone loss
marked weight loss
marked cell subpopulation
notable cell loss
substantial cell loss
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Justyna Jupowicz-Kozak
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