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EGF treatment of E2/TAM treated cells led to a marked cell proliferation thereby overruling the anti-estrogen-mediated inhibition of cell proliferation.
Fr-1 from both pregnant women induced a marked cell proliferation reaching a maximum RPE of 73 ± 4 and 38 ± 3, respectively.
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Therefore, PCNA can be used to mark cell proliferation and to identify a population of progenitor cells [ 20].
26 Thus, we performed PET imaging with FLT, a probe that marks cell proliferation, 27 before and after rapamycin treatment in tumour-bearing KC PTEN and KPC mice.
Deng et al. reported malignant characteristics as marked cell atypia, vascular invasion, high proliferation activity (Ki67 index above 30%), and large tumor size [32].
It has previously been shown that modulation of γδT cells activates αβT cells resulting in marked T cell proliferation.
In contrast, in chronic liver disease including HCV infection where there is marked endothelial cell proliferation, we observed reduced endothelial cell VEGFR-2 activation and a concomitant increase in BMP4 expression.
Phosphorylation of histone 3 (pH3) occurs during mitosis and marks active cell proliferation [ 27]. esgLacZ Indy YC0030/+ mutant flies have significantly fewer pH3-positive cells in midgut tissue compared to control esgLacZ/+ flies at 40 days (Fig. 3C,D, S4B).
At 0 2 hr after the L2-3 molt, 22/24 marked cells appeared to be isolated singles without marked neighbors, as would be expected prior to onset of proliferation and for the observed frequency of recombination (11%).
Development of epidermal ridges is first seen in the 10th 11th weeks of gestation and is marked by cell proliferations in the basal layer of the epidermis (Mulvihill and Smith 1969; Babler 1978).
Expression of full-length ERβ in hormone-responsive, ERα-positive MCF-7 cells resulted in a marked reduction in cell proliferation in response to estrogen and marked effects on the cell transcriptome.
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