"marked weight loss" is correct and usable in written English.
You can use it to describe a noticeable decrease in body weight. For example, "After two months of following a strict diet, James had a marked weight loss of 10 pounds."
Medical history revealed that the patient had also suffered from head tremor for many years and had experienced marked weight loss during adolescence.
We also observed marked weight loss and resolution of hypertension, dyslipidemia and hyperinsulinemia.
ptpn11 fl/fl ert2-cre mice exhibited marked weight loss prior to death (Fig. 1B).
High-dose 5-FU also induced marked weight loss (date not shown).
In contrast, chemotherapy was highly toxic determining marked weight loss in all mice and toxic deaths in a few mice.
However, at the dose of 300 mg/kg (starting dose), depression, decrease feed intake, diarrhoea, marked weight loss were noticed.
19 However, in these studies, HIPEC was associated with a considerable toxicity, indicated by lethargy, marked body weight loss, and bacterial translocation.
In addition, marked body weight loss was observed in cyclophosphamide-treated group compared to the control group, whereas only slight body weight loss was observed in TGA-treated groups.
Super high levels of circulating IL-22 (4000–7000 pg/ml) in IL-22TG8 mice or in mice treated with ad-IL-22 caused marked body weight loss in lean mice [ 14, 18], suggesting that super high levels of IL-22 induce cachexia.
Furthermore, AIF-1 mRNA levels in subcutaneous WAT were normalized in obese women from cohort 4 following marked long term weight loss (P < 0.01; Figure 3c).
Lifestyle changes in the form of dieting and/or exercise per se do not generally produce marked or sustainable weight loss (Dansinger et al., 2005; LeBlanc et al., 2011), whereas effective psychological therapies, such as cognitive behavioural therapy, cannot easily be delivered on a mass scale (e.g. Wing et al., 2006) and long-term results are disappointing.
