Sentence examples for mutations to achieve from inspiring English sources

Most importantly, the nanoparticles tackle multiple biological pathways found in a broad spectrum of microorganisms which may require many concurrent mutations to achieve resistance against the nanoparticle's antimicrobial activity.

This validates the significance and importance of these specific mutations to achieve a higher thermal tolerance in Synechocystis.

Importantly, inhibition of the mevalonate pathway prevents the activation of the UPRmt in normal worms, which explains the necessity for UPRmt-activating mutations to achieve resistance (Ranji et al. 2014; Liu et al. 2014).

As stem cells inherently possess this mechanism, the path to a functional cancer stem cell may therefore be considerably shorter than that for a differentiated somatic cell, which may have to acquire specific mutations to achieve the same self-renewing properties.

The approach modifies the complex placement strategies by proposing simple ones, whereas in the genetic algorithm we have modified the stages of initial population generation, crossover and mutation to achieve our objective.

Moreover, the artificial organisms that evolved under such a selection regime could quickly adapt between alternate goals (i.e. high genetic potential, with few mutations required to achieve high fitness after each environmental shift) (Kashtan et al. 2007).

Common mutations and hot spots are rare; therefore, there is a need for large and time-consuming mutation screenings to achieve a molecular diagnosis of RP in patients.

As for microbes, expanding offspring genome diversities by elevating replication mutation rates to achieve rapid adaptation and competitive advantages in harsh environments has been discovered and verified both in vivo[ 40- 42] and in silico[ 43, 44].

The best isobutanol producer strains constructed so far must be equipped with different mutations in order to achieve a high isobutanol yield, because the recombinants based on the transformation of wild type strains accumulate other intermediates and produce very low isobutanol yields (Atsumi et al. 2008; Atsumi and Liao 2008; Connor and Liao 2009; Gronenberg et al. 2013).

To determine the carrier frequency of ABCA4 mutations in order to achieve an insight into the prevalence of autosomal recessive Stargardt disease (arSTGD) in the Spanish population.

In our analysis of novel variants, we identified 16 genes for which the presence of somatic mutations predicted failure to achieve EFS24 at P<0.05, all odds ratios >7.0 (Table 2).