Sentence examples for mutations to acquire from inspiring English sources

Deregulation or failing of cell-cycle checkpoints and/or DNA repair mechanisms may lead normal cells bearing chromosome mutations to acquire neoplastic autonomy, which in turn can trigger the onset of cancer.

First, additional surveillance in higher-risk regions where viruses require fewer nucleotide mutations to acquire respiratory droplet transmission enabling substitutions (Fig. 1 and fig. S1) (and in regions connected by travel, trade, and migratory flyways) is key for monitoring the emergence of a respiratory droplet transmissible A/H5N1 virus.

The combination of INH resistance and maintained virulence might make it possible for some INH resistant strains, especially those with the katG315Thr mutation, to acquire extra drug resistance and become MDR-TB.

The primary aim of this study is to evaluate the contribution of the m.1555A > G mutation to acquired deafness in babies born at a gestational age of less than 32 weeks, who are likely to have received multiple doses of aminoglycoside antibiotics.

An analysis of the relative efficiency of tumorigenesis with and without a somatic mutator mutation, in the absence of lineage expansion (LE), demonstrated that mutator mutations enhance tumorigenic efficiency under many realistic scenarios, despite the need for an extra mutation step to acquire the mutator mutation itself [15].

This clone can acquire additional mutations to evolve into sub clones that can contribute to disease progression or relapse.

But just how difficult that mutation is to acquire "is something this research did not address," he says.

10.7554/eLife.06266.028 Appendix 1 figure 4. Sensitivity analysis of ( A ) the mutation rate to acquire drivers and ( B – D ) initial tumour size.

Variants that possess mutations enabling them to acquire better fitness, will now be selected.

Gene exchange is a common and evolutionarily safe strategy, as opposed to point mutations, for bacteria to acquire novel gene combinations for adaption to environmental stresses, novel conditions, or new niches [ 12].

To exclude the possibility of drug resistance mutations impacting on the entropy calculations, epitopes containing amino acid positions known to acquire mutations causing high, intermediate or low level resistance to RT and protease inhibitors (Stanford University Drug Resistance database) were removed from the list of epitopes and all the calculations were repeated.