Sentence examples for mutations to progress from inspiring English sources
But now, he added, it is becoming increasingly clear that cancers require more than mutations to progress.
As suggested by Davoli and de Lange (2011), such significant changes in tumour phenotypes is most likely caused by an enhanced ability of tetraploid tumours to sustain a higher incidence of mutations, thereby increasing the probability of adaptive changes and increasing the probability that evolving tumours will accumulate mutations needed to progress to a malignant state.
These lesions have high levels of the tumour-suppressor p21 and PTEN, suggesting that further mutations are required to progress these lesions.
In addition, mutations have been identified in U2AF1 in MDS patients, and those harboring U2AF1 mutations were more likely to progress to secondary AML.
Retrospective studies have identified that patients homozygous for JAK2V617F mutations are more likely to progress to post-PV MF.
These two mutation classes allowed RNA polymerase to progress downstream of the URA2 mRNA start site(s).
If the rate of progression of disease is related to the length of repeats, as seen in other repeat expansion diseases like spinocerebellar ataxias and Huntington's disease, this could also help to select certain populations of C9ORF72 mutation carriers who are expected to progress at the same rate.
Genetic deletion of Apc within LGR5 ISCs leads to rapid adenoma formation, whereas deletion within more differentiated lineages leads to poorly proliferative lesions that fail to progress without additional oncogenic mutations (Schwitalla et al., 2013).
"Nothing seems to progress".
