Sentence examples for mutations to avoid from inspiring English sources

We hypothesized that mutations to avoid FcγR binding would improve CAR+ T cell engraftment and antitumor efficacy.

In the upcoming era of genomic medicine, it will become imperative to counsel the next generations of individuals with germline telomerase mutations to avoid exposure to any agents that can harm those cells and organs that are especially sensitive to telomerase dysfunction.

Note also that in the more complex phylodynamic model we did include beneficial non-antigenic mutations, to avoid Muller's ratchet.

Given the likelihood that both configurations can form, we chose symmetrical configurations of mutations to avoid any ambiguity in the configurations of the subunits in the assembled hexamers.

For example, NBS-encoding genes that do not have useful functions in an environment lacking specific pathogens would more likely be lost or become pseudogenes through loss of function mutations to avoid a fitness cost.

This statistical test implies the definition of a background as the total set of genes that have been screened for mutations, to avoid bias in the results (Chittenden et al, 2008).

It was necessary to include the Δ rid mutation to avoid mutating the tcu-1 or nit-6 promoters during crosses of the transformants to wild-type.

The consensus sequence derived from simultaneous mutagenesis of too long a stretch of DNA will be loosely defined with a greater abundance R, W, S, Y, etc. instead of G, A, T, and C. In other words, to have maximal representation for all mutations and to avoid interference by secondary mutations, the length of DNA mutagenized should be kept at an optimal minimum.

To further analyze the H4 G94P and G94A mutations, and to avoid any plasmid copy number variation, we integrated the H4 G94andnd G94P mutations into the W1588 genetic background (Table 2).

Considering that C domains and P domains are hubs and bottlenecks of the DDI network respectively, this observation suggests that oncogenic mutations tend to avoid the topologically important nodes of the biological networks, probably because such mutations in key domains would lead to immediate breakdown of the whole system so become highly deleterious for cancer cell survival.

The NetrinG1 construct used for crystallization harbours two threonine to alanine mutations (T350A+T353A) to avoid predicted O-linked glycosylation.