Sentence examples for mutations to trace from inspiring English sources

Here, we have circumvented this problem by quantitatively using somatic mtDNA mutations to trace clonal lineages.

Here, we have measured the clonal evolution of stem cell populations within the human colon by using naturally occurring somatic mtDNA mutations to trace clonal lineages; this methodology circumvents the need to externally label cells in order to trace their progeny.

Other mutations are harder to trace because individuals with these mutations may develop very different signs and symptoms, or not develop clinical abnormalities at all.

Our method involves isolating and comparing somatic mutations in different subpopulations to trace lineage and infer mutational chronology.

Changes in mitochondrial genes can happen only by mutation, and the accumulation of such mutations can be used to trace ancestries.

The use of larger haplotypes with a higher recombination frequency would not maximise the information contained in the haplotypes but would point to a quite recent common ancestor in the case of haplotype homozygosity, which would be useful when trying to trace young mutations (e.g. disease mutations).

Further, Evrony and colleagues were able to use the mutations they found as markers to trace how progenitor cells migrate across the brain as it is formed.

Thus, many approaches for sequential monitoring of ctDNA have focussed on high-throughput techniques such as droplet and digital PCR to trace individual mutations in a patient's blood over time (Zheng et al. 2016).

Although introns have high mutation rates, making it difficult to trace lineages through sequence similarity, their positions are well conserved and can provide strong evidence to support conclusions on the origins of the genes [ 21].

In situations where a couple has the same mutation, analysis of single nucleotide polymorphism (SNP) can be used to trace the inheritance of mutations as the SNP can be with either of the alleles.

For the stop codons this should be not very difficult to trace to these mutations to specific branches of the evolutionary tree.