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Exact(4)

Since such mutations may reflect the selective forces experienced by a bacterium, they may also provide information on past propagation conditions.

In addition, the thioester bridge of the TED domain binds to pathogenic targets, thus the TED missense mutations may reflect its interactions with pathogens.

The clinical spectrum of cancers associated with germline hCHK2 mutations may reflect their relative contribution toward the function of p53 and/or BRCA1.

Therefore, the apparent alteration in PgR induction following E2 treatment of tissue from women with BRCA mutations may reflect an alteration in the PgRA to PgRB ratio such that PgRB expression is increased at the expense of PgRA.

Similar(56)

Their ability to adapt to new challenges upon mutation may reflect the nonpolar nature of their active sites as well as their high degree of conformational variability.

Elevated mutation may reflect differences in the natural history of the host species sampled.

The relatively small effect of the RPEL1 R81A mutation may reflect its failure to engage the F375actin carboxylate, whereas the RPEL1MAL-specific ionic interaction between R82 and E167actin provides a compensatory effect.

The ancestral clones contained Pik3ca/Kdm6a mutations and may reflect the field-disease mutations shared among later tumors.

Compared with the numbers of inactivating mutations expected per gene given random accumulation of mutations (fig. 5), there is an overrepresentation of genes with exactly one inactivating mutation, which may reflect large deletions masking mutations that occurred in deleted regions.

Analysis of the whole genome of HPAI A(H5N1) virus provides valuable insight into the presence of mutations that may reflect adaptive changes, altered virulence, and/or transmission phenotype.

Only two of the 22 cases without mutation in GRIM-19 gene showed a slightly elevated expression of the ICAM1 gene: the levels in these two cases were considerably lower (P=0.07) than those detected in four cases with mutations and may reflect alterations in pathways other than STAT3 pathway.

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