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TERT-p mutations may identify the rare subset of spitzoid melanocytic lesions prone to disseminate.
The researchers believe that searching the blood for such mutations may identify people at high risk of developing leukaemia who may, in the future, be targeted with preventative therapies.
30 The presence of activating BRAF mutations may identify a therapeutic target in the high-grade gliomas in which it is expressed.
Therefore, screening for TP53 mutations may identify additional PCM patients with an adverse prognosis who would not be detected by FISH analysis.
High EGFR gene copy number or activating EGFR mutations may identify patient subgroups who receive increased clinical benefit from vandetanib in combination with docetaxel in second-line NSCLC.
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Similarly, re-examining previous studies of drugs developed to treat ALS in light of this new mutation may identify novel FTD treatments.
The residual FRR for breast cancer may be driven by yet unidentified common variants that have similar patterns to those that have already been identified, that is more strongly associated with ER-positive than ER-negative disease, while GWAS restricted to ER-negative or BRCA1 mutation carriers may identify susceptibility variants associated with ER-negative disease.
Future studies may identify mutations or combinations of mutations that drive a specific phenotype.
Given the high copy number of the mtGenome and its rapid mutation rate, sequence analysis of the D-loop may identify mutations associated with these lesions in glandular organ-associated biofluids which are low in both volume and cellularity.
Evaluation of these loci in both hereditary and acquired SA cases that lack mutations in previously identified SA genes may identify novel mutations associated with this disorder.
We will discuss below how such mutations may help identify putative trans-splicing events in the dumpy gene.
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