Sentence examples for mutations may interfere from inspiring English sources
CXCR4 mutations may interfere with treatment response to ibrutinib.
Escape mutations may interfere with intracellular epitope processing [21], [22], disrupt peptide-HLA binding [23], [24], or disrupt recognition of the peptide/HLA complex by the T-cell receptor [25], [26].
Two of these mutations show abnormal CAPN3 signal on western blot [28], [29], suggesting that these mutations may interfere with normal CAPN3 autoregulation; a mechanism that was also recently suggested by Garnham et al. [30] The first step in the autolytic activation of CAPN3 is cleavage of the internal IS1 sequence.
Cut3 is an essential gene, and slc mutations may interfere with its expression.
However, recent studies have demonstrated that missense or silent mutations may interfere with normal splicing [ 26- 29].
First, PIK3CA mutations may interfere with the metastasis process or may induce senescence, which results in a better outcome for patients with mutated tumors.
Moreover, one can envision that such a mutation may interfere with substrate binding and, therefore, decrease rates of phosphorylation.
Since our findings show that the C-terminal domain of Orc6 is essential for the recruitment of Orc6 into Drosophila ORC, we hypothesized that the MGS mutation may interfere with this function.
Molecular modelling indicated that the mutation may interfere with the interaction of the bric-a-brac domain with Cullin 3. Coimmunoprecipitation experiments confirmed that the mutation reduces association with Cullin 3 in the Kelch-like homologue 9-Cullin 3 E3 ubiquitin ligase complex, which is involved in ubiquitin-dependent protein degradation.
The lower antibody responses in EBV-infected infants are consistent with the finding that EBV infection of B-cells induces mutations that may interfere with antibody production [18].
It is difficult to analyse the function of these deletion mutants because they coexist with some point mutations, which may interfere with the outcome.
