Epidemiological studies have suggested that the endogenous host environment, including reproductive history, body mass index, and BRCA germline mutation, may correlate with breast cancer features and prognosis [ 3– 11].
Conversely, we found only one case with the G12V change, thus reinforcing the knowledge that this type of mutation may correlate with an indolent clinical course (Finkelstein et al, 1993; Frattini et al, 2007).
Our findings indicate that routine tumor genotyping is helpful in identifying low-frequency mutations, such as GNAS, that may correlate with a specific morphological phenotype and also reveal multiplicity of concurrent mutations in a significant proportion of CRC that may have significant implications for clinical trial design and personalized therapy.
The results of the study suggested that the locus 168 missense mutation of the srtA gene may correlate with caries susceptibility of children with S. mutans.
Children carrying a G at locus 168 of S. mutans had a decreased risk for high-severity caries (OR = 0.32, 95% CI = 0.12 0.86) compared with those carrying a T. The present study suggested that the locus 168 missense mutation of the srtA gene may correlate with caries susceptibility in children with S. mutans.
Imaging features of glioblastomas may correlate with molecular mutations.
In line with this, Correale et al. demonstrated that activating KRAS mutations in colon cancer cell lines may correlate with a higher susceptibility to cetuximab-mediated ADCC [ 35].
It seems plausible that specific exposures may correlate with specific mutations in either stem or progenitor white blood cells due to their vulnerability to particular carcinogens at different stages of cellular growth and differentiation (Sandler et al, 1993).
Hence, the occurrence of length mutations may be correlated temporally.
Mutations in the nonstructural genes of DENV-2, isolated during the Santiago de Cuba epidemic, may correlate with increased efficiency of virus replication.
