Sentence examples for mutations may sensitize from inspiring English sources

We have learned that some mutations may sensitize the effects of a drug, while others may negate it.

Experiments in cultured cells and in knockout mice have hinted that DJ-1 mutations may sensitize cells to the harmful effects of oxidative stress.

Finally, the authors show some data suggesting that SPOP mutations may sensitize cells to PARP inhibitors, which have been shown to be synthetic lethal with BRCA1 mutations.

In the late AB subpopulation we also identified mutations in PIK3C2B and RPTOR, which may sensitize the tumor to a number of drugs that target the PI3K/Akt/mTOR signaling pathways.

Thus, it is likely that other factors in lung cancer cells may sensitize cells to gefitinib in addition to EGFR gene mutation and the amplification detected by FISH.

Besides mutations or lack of expression of BRCA molecules, deficiency of several other proteins involved in the HR pathway may sensitize cancer cells to PARPi.

Thus, the strategies for targeting these pathways may sensitize cancer cells to gemcitabine treatment.

Activation of pro-inflammatory pathways may sensitize microglial cells to promote hypoxia-induced injury of the developing brain.

It is fundamental to assess whether a preexisting injury may sensitize lungs to the deleterious effects of mechanical ventilation.

A "feeling for the [individual] organism" may sensitize a scientist to critical data (Keller 1983, Ruetsche 2004).

It is anticipated that chemotherapeutic agents may sensitize cells to CDK inhibition [35].