Sentence examples for mutations may reduce from inspiring English sources

Second, PNPLA3 mutations may reduce the mobilization of TAG on LDs (Pirazzi et al., 2012).

Mutations may reduce affinity of KCNE1 for KCNQ1, thereby decreasing the overall surface expression of functional channels.

These results show that targeting a polymorphic region potentially impairs amplification efficiency since potential mutations may reduce the affinity between the target region and the PCR primers and probes.

Other mutations may reduce an individual's fitness and are likely to be lost.

Collectively, analysis of the patient's myocardial tissue suggested that the desmosomal mutations may reduce Cx43 protein levels and phosphorylation but not overall distribution.

These mutations may reduce virologic susceptibility to treatment with non-nucleoside reverse transcriptase inhibitor-based regimens if initiated soon after delivery [ 3, 4].

Several roles for acj6 are compatible with this effect: the acj6-GAL4 mayation may reduce or alter activity in some neurons, such that photoexcitation can induce a jump response but normal stimuli cannot.

The increase in resting whole-cell KATP currents suggests that the T293N mutation may reduce channel inhibition by ATP, as found for other iDEND mutations.

Functional analysis: effects on K ATP channel ATP sensitivity The increase in resting whole-cell KATP currents suggests that the L164P mutation may reduce the channel ATP sensitivity, as found for other PNDM mutations [ 21].

Experimental deletion of virS in M. tuberculosis H37Rv resulted in pleiotropic cell wall defects and reduced growth in the spleen of guinea pigs (Singh et al. 2005), raising the possibility that this mutation may reduce the virulence of Lineage 1 strains.

In the negative clonal selection model (case 4), I introduce the input parameter NRFLN-D (Nreduced fitness loci net-dominant), which is an indicator of the vulnerability of the genome to mutations which may reduce cellular fitness [17].